GSTT1 is deregulated in left colon tumors.
نویسندگان
چکیده
Our aim was to determine GSTT1 expression levels in left colon tumors and paired normal tissue in order to identify specific alterations in GSTT1 mRNA levels. Alterations in GSTT1 expression in twenty-four left- sided colon tumors and paired cancer free tissue were determined by qRT-PCR. Significant fold changes were determined with t-test. When compared with cancer free tissue, left colon cancers showed a significant decrease in GSTT1 expression. However, GSTT1 mRNA levels among different grades increased gradually in correlation with tumor grade. Our results suggest that downregulation of GSTT1 in left-sided colon cancers is an early event and is reversed with cancer progression, probably due to cellular defense mechanisms as a response to changes in the microenvironment.
منابع مشابه
Evidence that the familial adenomatous polyposis gene is involved in a subset of colon cancers with a complementable defect in c-myc regulation.
Human colorectal carcinomas frequently express elevated levels of c-myc mRNA in the absence of a gross genetic change at the c-myc locus. To test the hypothesis that these tumors are defective in a gene function necessary for the regulation of c-myc expression, we fused an osteosarcoma cell line that exhibits normal c-myc regulation with two colon carcinoma cell lines that express deregulated l...
متن کاملنقش پلی‌مورفیسم‌های شایع ژن گلوتاتیون -S ترانسفراز در استعداد ابتلا به میوم رحمی
Background: Uterine myomas are benign tumors of the uterus and the most common solid pelvic tumors causing symptoms in approximately 25% of women in their reproductive years. However, its etiology and pathogenesis remain obscure there is increasing evidence that endometriosis is inherited as a complex genetic trait. Recent studies indicated the involvement of glutathione S-transferase M1 (GSTM1...
متن کاملSpontaneous Perforation of Rectosigmoid Colon
Spontaneous perforation of the sigmoid colon or rectom is defined as a sudden perforation of the colon in the absence of diseases such as tumors, diverticulosis or external injury. It is a very rare finding, and if neglected, results in severe peritonitis and high mortality. The causes of this rare condition are numerous, and in this case it might be due to the chronic constipation induced by a...
متن کاملDietary phytate lowers K-ras mutational frequency, decreases DNA-adduct and hydroxyl radical formation in azoxymethane-induced colon cancer
Objective(s): Dietary phytate is known to protect against azoxymethane (AOM)-induced preneoplastic lesions. The present study was designed to determine whether dietary phytate affects mutation frequency in colon epithelial cells challenged with azoxymethane in vivo, through lowering the formation of O6-methyl guanosine (O6-MeG) and 8-hydroxy deoxyguanosine (8-OHdG) ad...
متن کاملTreatment of Colon Carcinoma Tumors by Electrolysis: Effect of Electrical Dose and Polarity
Introduction: As a physical treatment, electrochemical therapy (ECHT) has provided an effective and useful approach for treating localized tumors. The chemical changes due to a direct electric current destroy the tumor. This study evaluates the effect of electrical dose and polarity on the efficacy of the treatment of a colon tumor model. Materials and Methods: In order to in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Asian Pacific journal of cancer prevention : APJCP
دوره 15 5 شماره
صفحات -
تاریخ انتشار 2014